Histone H3K27M is a driving mutation in diffuse intrinsic pontine glioma (DIPG)
組蛋白 H3K27M 是瀰漫性腦橋腦膠質瘤 (DIPG) 的驅動突變
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DMG:Diffuse midline glioma
DMG:瀰漫性中線膠質瘤
High EZH2 expression has been reported as a marker of poor prognosis in DMG-H3K27M [16].
據報導,高 EZH2 表達是 DMG-H3K27M 預後不良的標誌物 [16]。
節錄自https://link.springer.com/article/10.1007/s10014-020-00369-9
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EZH2 has been proved to be a potential therapeutic target for H3K27M-mutant pediatric gliomas recently.
最近已證明 EZH2 是 H3K27M 突變小兒神經膠質瘤的潛在治療靶點。
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Furthermore, we demonstrate that small-molecule EZH2 inhibitors abolish tumor cell growth through a mechanism that is dependent on the induction of the tumor-suppressor protein p16INK4A. Genome-wide enrichment analyses show that the genes that retain H3K27me
此外,我們證明小分子 EZH2 抑製劑通過依賴於腫瘤抑制蛋白 p16INK4A 誘導的機制消除腫瘤細胞生長。 全基因組富集分析表明,保留 H3K27me 的基因
As inhibition of EZH2 activity could upregulate the expression of tumor suppressor genes, EZH2 has recently become an interesting therapeutic target for cancer therapy.
由於抑制 EZH2 活性可以上調腫瘤抑制基因的表達,因此 EZH2 最近已成為癌症治療的一個有趣的治療靶點。
EZH2-inactivated naïve CD8+ T cells showed increased production of IFN-γ, interleukin (IL-2), and GZMB after stimulation in vitro (39).
EZH2 滅活的初始 CD8+ T 細胞在體外刺激後顯示 IFN-γ、白細胞介素 (IL-2) 和 GZMB 的產生增加 (39)。
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因此IFN-γ、白細胞介素 (IL-2)等於是滅活EZH2、EZH2 inhibitors,EZH2 抑製劑。
an IL-4 stimulus, inhibition of Ezh2 with GSK343 demonstrated modest but significant (p b 0.05) upregulation of M2-related genes.
在 IL-4 刺激下,GSK343 對 Ezh2 的抑制表現出適度但顯著的 M2 相關基因上調(p = 0.05)。
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Moreover, inhibition of EZH2 with GSK343 in the presence of an IL-4 stimulus
此外,在 IL-4 刺激存在下用 GSK343 抑制 EZH2
we observed that EZH2 inhibition slightly increased IL-10-induced IL10 gene expression
我們觀察到 EZH2 抑制略微增加了 IL-10 誘導的 IL10 基因表達
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可能也是因為增加了IL-10才抑制EZH2
總結以上:
建議全面提升四大免疫因子來消除腦腫瘤
病毒感染,吃這些消滅病毒!Part-II
告訴我們:
能提高IL-4的元素:
鎂、鋅、鈣、維生素A、維生素C、兒茶素、茄紅素、薑黃素、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-10的元素:
鎂、鈣、鋅、錳、硒、維生素A、維生素D、維生素E、兒茶素、花青素、薑黃素、鐵、碘、茄紅素、黃酮類化合物(生物類黃酮、大豆異黃酮)、鞣花酸
能提高IL-2的元素:
鋅、銅、硒、鈣、維生素A、維生素C、維生素E、大豆異黃酮、兒茶素、花青素、茄紅素、多醣體(燕麥多醣體)、牛磺酸
能提高IFN-γ的元素:
鋅、硒、錳、維生素A、維生素C、高劑量維生素E、兒茶素、茄紅素、大豆異黃酮、多醣體(燕麥多醣體)